THC isomer

Delta-10
Cannabinoids

A THC isomer is a compound with the same chemical formula as delta-9 THC but a different arrangement of atoms, such as delta-8 THC and delta-10 THC.

Isomers share the formula C21H30O2 but differ in the position of a double bond or in three-dimensional shape, which changes how strongly they bind cannabinoid receptors. Delta-9 THC is the main intoxicating cannabinoid in cannabis. Delta-8 THC occurs naturally in trace amounts and binds CB1 with somewhat lower affinity, producing similar but milder effects. Delta-10, THC-O acetate and other variants sold in recent years are made chemically from hemp-derived CBD rather than extracted from the plant.

Federal hemp law defines hemp by delta-9 THC content, which created a gap that manufacturers used to sell intoxicating isomers derived from legal hemp. Regulators have responded with warnings about products that reach the market without safety testing, and many states have restricted or banned them; the U.S. Food and Drug Administration has noted reports of adverse events, including in children and pets, linked to these products. Isomers can also register on drug tests. Little formal research exists on any THC isomer other than delta-9.