Everything we know about CBD, in one place.

Guides, research, customer stories and a reference index of every term we use. Each piece is filed by topic, so one thread leads to the next.

CBD 101

CBD Fundamentals

Guide · 3 min CBDCannabidiol What the compound is, how the body processes it, and what the evidence supports.Read the guide Guide · 1 min CBGCannabigerol Where the "mother of all cannabinoids" sits in the plant, why it is scarce, and what it is studied for.Read the guide Guide · 8 min CBNCannabinol The cannabinoid most associated with rest, and what the sleep literature actually shows.Read the guide
Watch · [RUNTIME]

Dr. Dorninger on the fundamentals

The overview talk: what the compound is, how the body handles it, and what the research does and does not show. The slides come with it.

Watch the talkThe presentation
Articles, stories & more

Browse The Library

Guide3 min What CBD is, and what it does Guide1 min CBG — the mother cannabinoid Guide8 min CBN — the sleep cannabinoidCannabinoids · Sleep Story12 min CIRS, Mold Exposure & CBD: Lauren’s Recovery StoryDaily wellness Research4 min CBD for MCAS & Histamine: What Does Research Say?Cannabinoids · Research Research2 min What Does the Research Say About CBD, Sleep and Anxiety?Sleep · Research Story1 min Giving Your Dog More Good Days: Crosby's StoryPain & recovery · Daily wellness Article2 min Listen Now: Dr. Dorninger on the Flipping50 Podcast - CBD + MenopauseDaily wellness · Sleep Research2 min Can CBD Help Reduce Exercise-Related Inflammation?Pain & recovery · Research Research2 min CBD for Pet Anxiety: What the Latest Research SaysDaily wellness · Research Guide1 min Why Your CBD May Not Be WorkingCannabinoids Guide2 min Ask Dr. D: How-To Reduce Inflammation in Your 40'sPain & recovery · Daily wellness Research3 min CBD for Everyday Insomnia: What the Latest Research Says About Better RestSleep · Research Article1 min Navigating Menopause and Sleep Changes: Tips for Better RestSleep · Daily wellness Story2 min When Sleep Finally Feels Like Sleep Again : From 50 to 94 Sleep ScoreSleep Article1 min The 2-Minute Habit That May Support LongevityDaily wellness Research2 min CBD for High Blood Pressure: What the Latest Research Says About HypertensionDaily wellness · Research Guide5 min Why Sleep is the Missing Link in Your Wellness Routine — And What to Do About ItSleep Research1 min 79% Saw Reduced Anxiety in a CBD Study—Here’s What That MeansDaily wellness · Research Story2 min Autumn's Sleep Score went from 74 to 100- overnight!Sleep Article1 min What to Know About Exercise and Menopause (and Why It Matters More Than You ThinkDaily wellness Research1 min What the Research Shows: Why People Are Turning to CBD for Stress, Sleep, and Everyday BalanceDaily wellness · Research Film2 min Sleep, Inflammation, and Anxiety During Menopause: How Cannabinoids May Help Support BalanceSleep · Daily wellness Story1 min Mobility, Golf, and Long Workdays: How CBD Fits Into Rob's Active LifestylePain & recovery Film1 min Listen Now: Dr. Eric Dorninger on The Advisor: Health & Healing PodcastSleep · Daily wellness Article1 min Why So Many Women in Midlife Are Sleeping Poorly — and What Breathing Has to Do With ItSleep · Daily wellness Research1 min What the Science Says About CBD & Anxiety: Why Research (and Education) MatterDaily wellness · Research Article1 min 5 Healthy Habits That May Help Keep the Brain Younger : Even with Chronic PainPain & recovery · Daily wellness Research2 min What the Research Says About CBD, Sleep, and AnxietySleep · Research Film2 min Dr. Dorninger on CBD, Menopause, and Restorative Sleep: Supporting Balance NaturallySleep · Daily wellness Article2 min The Benefits of Meditation and How Blue Sky CBD Original Formula May Support Mood RegulationDaily wellness Film4 min Struggling to Sleep? How CBD + CBN May Help Restore Your SleepSleep Guide2 min Unlock Better Rest: Healthy Sleep Habits + How CBD Fits InSleep Story2 min Perimenopause Was Winning. Then She Tried Blue Sky CBD.Daily wellness · Sleep Research1 min A New Look at CBD and Brain Health: What Science Is Revealing About Alzheimer’sDaily wellness · Research Article1 min Finding Calm During Holiday StressDaily wellness Story1 min Listen Now: Blue Sky Customer Laura Scott on the Flipping50 Podcast Talking MenopauseDaily wellness · Sleep Story2 min Lyme Nearly Stole 17 Years—Here’s How Kristen Fought BackDaily wellness Story6 min Sleepless in Denver: A Radio Host’s Journey Toward RestSleep Article1 min The Best (and Worst) Exercises for Older AdultsDaily wellness Story1 min Sharon's Story : A Lifetime of Pain, A New Path to ReliefPain & recovery Research1 min CBD + Chronic Pain: What a Systematic Review FoundPain & recovery · Research Research1 min CBD and Inflammation: What Research Tells UsPain & recovery · Research Research1 min Fighting Inflammation Starts Here — Backed by SciencePain & recovery · Research Article1 min 10 Time-Saving, Science-Backed Fitness Tips to Level Up Your Workouts in 2025Daily wellness Research1 min Study finds 20mg of CBN May Help You Wake Up LessSleep · Research Story1 min Kalila's Sleep Was Interrupted, Now It's SolidSleep Film1 min Watch Now: How Flipping 50’s Debra Atkinson and Dr. Eric Dorninger Are Changing the Conversation Around CBD and MenopauseDaily wellness · Sleep Story2 min Listen Now: Radio Host Mandy Connell Shares How Her Sleep Scores Improved from 40 to 90 OvernightSleep Story3 min CBD Saved My Sleep and Sanity: My Menopause BreakthroughSleep · Daily wellness Article1 min Hydration First: Why Seniors Must Prioritize Water During Summer WorkoutsDaily wellness Research3 min Dr. D Shares His Thoughts: How Short-Term Sleep Deprivation Impacts Your Heart Health: What a New Study RevealsSleep · Research Article1 min Evening Habits That Support Healthy AgingDaily wellness · Sleep Story2 min How Nick Found Relief from Nerve Pain—and Helped His Wife Beat Sciatica TooPain & recovery Article1 min The Power of Connection: Why Socializing Matters as We AgeDaily wellness Story1 min From Office Chair to Zumba Class: Kalila’s Go-To for Real ReliefPain & recovery Story1 min Finding Relief: How Blue Sky CBD Helped Ease Annette’s Arthritis PainPain & recovery Research1 min How CBD May Help People Sleep Better, According to ResearchSleep · Research Article1 min Stronger With Age: Why Strength Training MattersDaily wellness Story1 min CBD and Cancer: One Family’s Powerful ExperiencePain & recovery · Daily wellness Story2 min Amity’s Story: Finding Relaxation and Relief with Blue Sky CBD Bath BombsDaily wellness · Pain & recovery Research1 min Strength Training and Sleep: How Exercise and CBD May Help Older Adults Overcome InsomniaSleep · Research Story3 min Manny's Story: From Sciatica to Strength-How Blue Sky CBD’s Max Relief Balm May Help with Pain ReliefPain & recovery Film1 min Watch Now: CBD & Aging Well-How It May Support Healthy AgingDaily wellness · Pain & recovery Article1 min The Transformative Benefits of Tai Chi for Mind and Body Over 50Daily wellness Story3 min How CBD Helps Ginger Travel in RetirementPain & recovery · Daily wellness Film1 min Watch Now: Exploring the Power of CBD and How It May Relieve PainPain & recovery · Cannabinoids Research1 min Exploring CBD for Treatment-Resistant Fibromyalgia: Insights from a Recent StudyPain & recovery · Research Article2 min Top 25 Wellness Trends to Embrace in 2025Daily wellness Article1 min How to Reduce Fall Risks for Older Adults: Expert Tips"Daily wellness Story1 min A 15-Year Journey to Lasting CBD Pain Relief: Gerry’s StoryPain & recovery Story1 min From Struggle to Relief: Sheri’s Journey with Severe Anxiety and InsomniaSleep · Daily wellness Research1 min Finding Calm with CBD: Research Highlights Its Potential for Anxiety ReliefDaily wellness · Research Article1 min 8 Simple Ways to Slow Down this Holiday and Find Joy in the SeasonDaily wellness Research1 min The Surprising Connection Between Marijuana Use and Lost SleepSleep · Research Research1 min Unlocking the Benefits of CBD in Cancer Care: Symptom Relief and Treatment SupportDaily wellness · Research Story1 min Brandi's Journey with Chronic Pain: How Blue Sky CBD Changed EverythingPain & recovery Article2 min Staying Healthy Through Holiday Stress: Simple Tips for a Joyful SeasonDaily wellness Story1 min Finding Relief: My Journey with Parkinson’s and the Benefits of CBDDaily wellness Article1 min Unlocking Restful Sleep During Menopause: Insights from Dr. DorningerSleep · Daily wellness Article1 min Understanding and Managing Fatigue in Older Adults: Causes, Symptoms, and SolutionsDaily wellness Story1 min Anita's Story: Hypertension + Blue Sky CBDDaily wellness Film1 min CBD 101: Dr. Dorninger's Overview of CannabidiolCannabinoids Research2 min Alzheimer's + CBD: Exploring the BenefitsDaily wellness · Research Story1 min Jeffrey's Story: Finding Relief and Recovery from CIRS with Blue Sky CBDDaily wellness Article1 min Unlocking Peak Performance: Why Blue Sky CBD's Pro Line is Perfect for the Athlete in All of UsPain & recovery Research1 min Can CBD Be a Game Changer for Migraine Sufferers?Pain & recovery · Research Article1 min Hydration Linked to Healthy AgingDaily wellness Story1 min Nancy's Story: A Journey of Resilience and HealingDaily wellness Article1 min A PT Recommended Stretching RoutinePain & recovery Research1 min CBD + Anxiety : Why Zero THC MattersDaily wellness · Research Article1 min Blue Sky CBD Feature in CannabisTechDaily wellness Article1 min CBD + Older Adult WellnessDaily wellness Research1 min Study Shows How CBD Decreases Anxiety, Neuropathic PainPain & recovery · Research Story1 min Sue's Knee Replacement StoryPain & recovery Article1 min How to Heal Your Body with the Right FoodsDaily wellness Story1 min Connie's Story As Featured in First for Women MagazineDaily wellness Guide2 min 5 Tips to Ensure A Good Night's Sleep from Dr. DSleep Research1 min The Potential Role of Cannabidiol in Sports RecoveryPain & recovery · Research Research1 min CBD + Concussions | Everything You Need To KnowPain & recovery · Research Research1 min Study Reflects 20 MG of CBN Improves SleepSleep · Research Article1 min Dr. Dorninger Interview on the Health or High Water PodcastDaily wellness Film1 min Dr. Kelsey Asplin Talks Blue Sky CBD on Denver 7's Mile High LivingDaily wellness Research1 min A Single Dose of Cannibidol Reduces Blood Pressure As Detailed in Randomized StudyDaily wellness · Research Guide3 min Sleep Wellness for 50+ By Dr. Eric DorningerSleep Article1 min Blue Sky CBD Bath Bombs Blog FeaturePain & recovery · Daily wellness Film1 min Dr. Eric Dorninger on Denver 7's Mile High LivingDaily wellness Article1 min CBD + Menopause | Dr. Dorninger on the Flipping50 Podcast with Debra AtkinsonDaily wellness · Sleep Article1 min Dr. Dorninger on Max & Amy in the MorningDaily wellness Research1 min Can CBD Help with Migraines?Pain & recovery · Research Research1 min CBD for Alzheimer's + Parkinson's DiseasesDaily wellness · Research Research1 min CBD + FibromyalgiaPain & recovery · Research Article1 min Founder Greg Carpenter and Dr. Eric Dorninger on It's A Wrap with Rap PodcastDaily wellness Research1 min Cannabidiol For ArthritisPain & recovery · Research Article1 min Dr. Eric Dorninger on What Well Women Want PodcastDaily wellness Research1 min CBD + Healthcare Worker BurnoutDaily wellness · Research Research1 min National Institute of Health on Antioxitive and Anti Inflammatory Properties of CBDCannabinoids · Research Guide2 min CBD Basics from Dr. Eric Dorninger, NDCannabinoids Guide2 min Five ways to combat inflammation from Dr. Dorninger, NDPain & recovery · Daily wellness Research1 min CBD for Depression + StressDaily wellness · Research Research1 min Read Now | News Medical Life Sciences Article on CBD + Parkinson'sDaily wellness · Research Story1 min Read Now | How CBD Worked to Lower Anita's Blood PressureDaily wellness Research1 min Study Finds CBD Effective in Treatment of Neuropathy SymptomsPain & recovery · Research Film1 min WATCH NOW | How Blue Sky CBD Can Make A Difference For YouDaily wellness Film1 min WATCH NOW | How and When to Use Blue Sky CBDDaily wellness · Cannabinoids Story1 min Suzie's Story in Woman's WorldPain & recovery Film1 min Watch Now | Dr. D on Sleep + Blue Sky CBDSleep Film1 min Watch Now | Dr. D on Anxiety + Blue Sky CBDDaily wellness Film1 min Watch Now | Dr D on Chronic Pain + Blue Sky CBDPain & recovery Film1 min Dr. D Talks the Blue Sky DifferenceDaily wellness · Cannabinoids Film1 min Phytocannibinoids! Learn more about CBD, CBG and CBN from Dr. Eric DornignerCannabinoids Film1 min Dr. Eric Dorninger, Blue Sky CBD Research + Development Director, Featured on Channel 2 Talking Healthy Sleep HabitsSleep Guide5 min CBD + CBG OverviewCannabinoids Research5 min CBD Oil for Parkinson’s: Does It Work?Daily wellness · Research Research7 min CBD Oil for Anxiety: What the Research Has to SayDaily wellness · Research Research9 min CBD Oil for Pain: What Existing Research ShowsPain & recovery · Research Article2 min Insomnia | Q & A with Dr. Eric DorningerSleep Guide3 min 5 Benefits of CBD: Your Guide to Balms and Topicals for PainPain & recovery Guide3 min Find the Right CBD: Natural Remedy For Your NeedsCannabinoids · Daily wellness Guide3 min Does CBD Oil Work For Dogs? The Benefits of CBD Oil for Pets.Daily wellness Guide4 min When to Take CBD For Sleep: Benefits and What You Need To KnowSleep Article1 min GOOD DUDES GROW PODCAST WITH DR. DORNINGERCannabinoids · Daily wellness Article1 min CAREGIVING PODCAST SERIES: CBD EXPLAINEDCannabinoids · Daily wellness Film1 min WATCH NOW | CBD 101: A PRACTITIONER'S OVERVIEW OF CANNABIDIOLCannabinoids Film1 min WATCH NOW | DR. D EXPLAINSCannabinoids Reference1 min Client TestimonialsDaily wellness
Nothing is filed under both of those.

The narrower of the two filters is usually the one to drop. Or start from a single topic and widen from there.

Browse the research
Research

The evidence, by ailment

Peer-reviewed studies grouped by what they examined, each with a plain-English summary of its findings.

The research library
A cannabidiol aminoquinone derivative activates the PP2A/B55α/HIF pathway and shows protective effects in a murine model of traumatic brain injury.Preclinical · 2022A double-blind, randomized, placebo-controlled, parallel group study of THC/CBD spray in peripheral neuropathic pain treatment.Randomised · 2014A double-blind, randomized, placebo-controlled study of the safety and effects of CBN with and without CBD on sleep quality.Randomised · 2024A Randomized Controlled Trial of Topical Cannabidiol for the Treatment of Thumb Basal Joint Arthritis.Randomised · 2022A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis.Randomised · 2018A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study.Study · 2017A Systematic Review and Meta-Analysis of the Haemodynamic Effects of Cannabidiol.Study · 2017A time-series study of sick building syndrome: chronic, biotoxin-associated illness from exposure to water-damaged buildings.Observational · 2005Action of cannabidiol on the anxiety and other effects produced by delta 9-THC in normal subjects.Clinical trial · 1982Acute Effects of Cannabis Inhalation on Arterial Stiffness, Vascular Endothelial Function, and Cardiac Function.Clinical trial · 2024Adverse effects of cannabidiol: a systematic review and meta-analysis of randomized clinical trials.Systematic review · 2020Adverse Effects of Oral Cannabidiol: An Updated Systematic Review of Randomized Controlled Trials (2020-2022).Review · 2022An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia.Randomised · 2019An open-label feasibility trial of transdermal cannabidiol for hand osteoarthritis.Clinical trial · 2024An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies.Review · 2017Antioxidative and Anti-Inflammatory Properties of Cannabidiol.Review · 2019Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis.Preclinical · 2017Biomarkers over Time: From Visual Contrast Sensitivity to Transcriptomics in Differentiating Chronic Inflammatory Response Syndrome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.Review · 2025Cannabidiol acts as molecular switch in innate immune cells to promote the biosynthesis of inflammation-resolving lipid mediators.Clinical (other) · 2023Cannabidiol and Alzheimer's disease.Review · 2024Greco R, et al. J Headache Pain. 2023. CBD reduces NTG-induced hyperalgesia, CGRP, and IL-6 in rodent migraine models. BioMed CentralStudy · 2023Cannabidiol as a Novel Therapeutic for Immune Modulation.Review · 2020Cannabidiol as a Potential Treatment for Anxiety Disorders.Review · 2015Cannabidiol as a treatment for arthritis and joint pain: an exploratory cross-sectional study.Study · 2022Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case series.Case report · 2014Cannabidiol causes endothelium-dependent vasorelaxation of human mesenteric arteries via CB1 activation.Clinical (other) · 2015Cannabidiol (CBD): a killer for inflammatory rheumatoid arthritis synovial fibroblasts.Clinical (other) · 2020Cannabidiol (CBD): A Systematic Review of Clinical and Preclinical Evidence in the Treatment of Pain.Review · 2024Cannabidiol-enriched cannabis extraction product in Parkinson's disease: A randomized, double-blind, and placebo-controlled trial in Buriram Hospital.Study · 2022Cannabidiol for moderate-severe insomnia: a randomized controlled pilot trial of 150 mg of nightly dosing.Randomised · 2024Cannabidiol for Scan-Related Anxiety in Women With Advanced Breast Cancer: A Randomized Clinical Trial.Randomised · 2024Cannabidiol for Treatment-Resistant Anxiety Disorders in Young People: An Open-Label Trial.Clinical trial · 2022Cannabidiol in Anxiety and Sleep: A Large Case Series.Observational · 2019Cannabidiol in Parkinson's disease.Clinical (other) · 2020Cannabidiol Interactions with Medications, Illicit Substances, and Alcohol: a Comprehensive Review.Review · 2021Cannabidiol prevents LPS-induced inflammation by inhibiting the NLRP3 inflammasome and iNOS activity in BV2 microglia cells via CB2 receptors and PPARγ.Preclinical · 2024Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients.Randomised · 2011Cannabidiol's neuroprotective properties and potential treatment of traumatic brain injuries.Review · 2023Cannabidiol treatment in hand osteoarthritis and psoriatic arthritis: a randomized, double-blind, placebo-controlled trial.Randomised · 2022CBD use in FM—survey/observational: high uptake, perceived benefit (uncontrolled). ; JPain+1StudyCannabidiol versus placebo in patients with fibromyalgia: a randomised, double-blind, placebo-controlled, parallel-group, single-centre trial.Randomised · 2026Cannabinoid therapies in the management of sleep disorders: A systematic review of preclinical and clinical studies.Systematic review · 2020Cannabinoid treatments for anxiety: A systematic review and consideration of the impact of sleep disturbance.Systematic review · 2022Cannabinoids Alleviate the LPS-Induced Cytokine Storm via Attenuating NLRP3 Inflammasome Signaling and TYK2-Mediated STAT3 Signaling Pathways In Vitro.Clinical (other) · 2022Cannabinoids & neuropathic pain (reviews): AHRQ Living Review (2023–24). ; Johnson BW, Biomedicines 2025. ; Strand N, Pain Ther 2023. NCBI+2PMC+2Study · 2025Cannabinoids as Key Regulators of Inflammasome Signaling: A Current Perspective.Review · 2020Cannabinoids for fibromyalgia.Systematic review · 2016Cannabinoids for the treatment of dementia.Systematic review · 2021Cannabinoids in Late Life Parkinson's Disease and Dementia: Biological Pathways and Clinical Challenges.Review · 2022Cannabinoids in traumatic brain injury and related neuropathologies: preclinical and clinical research on endogenous, plant-derived, and synthetic compounds.Review · 2023
The indexOpen the full index

The Language of CBD

ABCDEFGHIJKLMNOPQRSTUVWXYZ
0.3 percent THC limit
The 0.3 percent THC limit is the federal threshold, measured as delta-9 THC by dry weight, that separates lawful hemp from marijuana under the Controlled Substances Act.
2-Arachidonoylglycerol (2-AG)
2-Arachidonoylglycerol, or 2-AG, is the most abundant endocannabinoid in the body, a lipid messenger that fully activates both CB1 and CB2 receptors.
2018 Farm Bill
The 2018 Farm Bill, formally the Agriculture Improvement Act of 2018, is the federal law that removed hemp from the Controlled Substances Act and set its legal definition.
Absorption, distribution, metabolism and excretion (ADME)
ADME describes the four stages a substance passes through in the body: absorption into the bloodstream, distribution to tissues, metabolism into other compounds, and excretion.
Abstinence
Abstinence is the sustained, deliberate avoidance of a substance such as alcohol, tobacco, cannabis or opioids, and is the most common outcome measured in addiction research.
Abuse liability
Abuse liability is a drug's potential to produce rewarding effects that lead to repeated non-medical use, dependence or addiction, assessed formally before a drug is scheduled or approved.
Accredited laboratory
An accredited laboratory is one that an independent accrediting body has assessed against a published standard and found competent to perform specific tests.
Acne
Acne is a common inflammatory skin condition in which hair follicles and their attached sebaceous glands become clogged, producing blackheads, whiteheads and pimples.
Actigraphy
Actigraphy is a method of estimating sleep and wake patterns over days or weeks by recording body movement with a small wrist-worn sensor.
Presentations
CBD: an overviewPDF · Dr. DorningerPain managementPDF · Dr. DorningerMental health applicationsPDF · Dr. Dorninger
Common questions