Dependence

Dependence is a state in which the body has adapted to a substance so that stopping or sharply reducing it produces withdrawal symptoms.

Physical dependence is distinct from addiction, although the two are often confused. Dependence describes an adaptation that can occur with many prescribed medications, including some blood pressure drugs and antidepressants, and it does not by itself imply compulsive use. Addiction, or substance use disorder, involves loss of control and continued use despite harm. Clinicians assess dependence by the presence and pattern of withdrawal signs when a substance is stopped.

A World Health Organization review concluded that cannabidiol does not appear to have abuse or dependence potential in the studies examined, and prescription CBD is not a controlled substance in the United States. This profile differs from THC, which can produce a recognized withdrawal syndrome in regular heavy users. Evidence on long-term daily use of retail cannabinoid products is limited, so absolute statements should be avoided. Readers meet this term in regulatory scheduling documents and in consumer questions about safety.