“Overall experience was good. Once I put the gel on, my knees felt better with less pain.”
The best CBD for pain - powered by CBG .
From workouts to workdays, ease every ache naturally with the zero THC Max Relief Formula.
The Science of CBD & CBG
Cannabidiol (CBD) and cannabigerol (CBG) are two prominent non-intoxicating cannabinoids found in cannabis plants. While CBD has gained widespread recognition in recent years, CBG is emerging as an equally promising compound with unique properties. When used together, these cannabinoids may offer enhanced benefits through what researchers call the "entourage effect."
Both CBD and CBG interact with the body's endocannabinoid system (ECS), a complex cell-signaling network that helps maintain homeostasis. However, they do so in different ways:
- CBD doesn't directly bind to cannabinoid receptors but influences them indirectly while affecting other receptor systems
- CBG directly binds to both CB1 and CB2 receptors and may block enzymes that break down endocannabinoids
When CBD and CBG work together, they may enhance each other's beneficial properties while potentially mitigating unwanted effects—a synergistic relationship known as the entourage effect. Research suggests these cannabinoids may offer similar yet distinct potential benefits:
- Anti-inflammatory effects: Both compounds show promise in reducing inflammation through different pathways
- Neuroprotective potential: Each may support neurological health in unique ways
- Anxiety and stress response: Together, they might offer more comprehensive mood support
Looking for more information? Read published research or watch CBD 101 with Dr. Eric Dorninger, ND
Your Wellness - Grounded in Science
Our formulation process is designed for uncompromising quality. When you visit our Trust Center, you’ll find easy access to lab reports, published research, and presentations from Dr. Dorninger - all in one place.
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Why People Love Blue Sky
“This is the best pain relieving balm, EVER - BAR NONE!!”
“After trying frankensence, turmeric, magnesium, and another CBD cream, we can say Blue does the job.”
“My mom is 96 with severe cervical stenosis with arthritis. Within 2 weeks she was moving much better with less discomfort. We will continue to use this product”
“Love your product, best I have found, particularly the gel combined with the balm.”
“The Max Relief gels really help subside my lower back pain.”
Commonly Asked Questions
The best strength of CBD for pain depends on the type and intensity of discomfort, but most people start with 10–20 mg per day orally and gradually increase. For moderate to chronic pain, doses of 20–40 mg/day are common, while severe or nerve-related pain may require 50–100+ mg/day, often with medical guidance. In addition to oral CBD, CBD balms and topicals are popular for localized pain (e.g., joints, muscles) and typically contain 200–1000 mg of CBD per jar, applied directly to the skin. These balms don’t enter the bloodstream but can provide fast, targeted relief for surface-level or joint pain. As always, it’s best to start low, go slow, and consult a healthcare provider when needed.
CBD and ibuprofen relieve pain through different mechanisms, and whether one is better depends on the situation. Ibuprofen is a fast-acting, well-studied anti-inflammatory drug effective for acute pain but carries risks with long-term use, such as stomach or kidney issues. CBD, on the other hand, works by modulating pain and inflammation through the endocannabinoid system and tends to have fewer serious side effects. Some studies suggest CBD may be as effective as ibuprofen for specific conditions like joint pain or TMJ disorders, especially when used as a topical. However, CBD is slower-acting and less standardized. For acute pain, ibuprofen is generally more reliable, while CBD may be a safer alternative for chronic pain or in individuals who can’t tolerate NSAIDs.
Combining CBD with CBG may enhance pain relief, especially for inflammatory, nerve-related, or visceral pain. While CBD interacts with the endocannabinoid system to reduce pain and inflammation, CBG targets different receptors (like TRPV1 and α2-adrenergic) and may reduce pain hypersensitivity and inflammation in complementary ways. Preclinical studies suggest the combination is more effective than either alone in some models, but human trials are still limited. Early results are promising, especially in conditions like colitis or chronic hyperalgesia, though optimal dosing and long-term safety are not yet fully established. Overall, CBD+CBG blends may offer broader, more potent pain relief than CBD alone.
At Blue Sky CBD, we’ve been serving our community with potent, pure CBD oil extracts for years. During this time we’ve come across several extreme cases that needed something a little more in terms of relief from aches, pains, stiffness, stress, and more.
After years of research and testing, we launched our Maximum Relief formula which is a novel and high concentration blend of CBD & CBG. CBG is a unique cannabinoid, one that’s converted to other cannabinoids within the plant. This has led to CBG being called “the Mother of all Cannabinoids.”
Because CBD and CBG influence health via different pathways, they each offer unique health benefits. When taken together, you reap the individual benefits simultaneously. Our experiences show us that adding CBG to our CBD is a big step up from our standard 3000mg CBD products. With over 3000mg of CBD + 1700mg of CBG, this is a blend that we suggest for our most difficult and troubling cases.
At Blue Sky, we believe in the purest formulas to create the strongest impacts. Our products contain no flavors, dyes, or unnecessary fillers – only 100% pure, potent CBD. By eliminating THC, we allow our products to be more readily recommended by medical professionals and accessible across our country.
This is a question that, unfortunately, does not have a simple answer. Currently, most of the published research on the benefits and safety of CBD has been conducted with CBD isolate, not on the benefits or side effects of full-spectrum hemp oil. This is why Blue Sky CBD brings our customers the highest-quality CBD isolate products.
When it comes to health and wellness, full-spectrum advocates appreciate the wide variety of healthful compounds found within. Cannabinoid isolates, like CBG or CBD isolate, allow you to focus entirely on the health benefits associated with specific cannabinoids. This makes it easier to find your best CBD oil dosage. Additionally, CBD isolate oil is less expensive than full-spectrum oil.
Another reason we like pure CBD oil and other isolate-based products is because they remove variables that could complicate the health effects. For instance, certain cannabinoids are known to cause drowsiness, which is an unwanted side effect for some consumers. By using isolated cannabinoids, we guarantee that our customers receive the same product time and again. This helps you find the right dosage and product for your wellness goals.